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Valacyclovir (Valclovir 1000) 1000 mg Tablet

$212.18

Valaciclovir (Valacyclovir) is a nucleoside analog DNA polymerase inhibitor. It is an antiviral drug that is used to manage and treat various herpes infections. Each tablet contains 1000 mg of Valacyclovir as its active ingredient.

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Valaciclovir (Valacyclovir) is a nucleoside analog DNA polymerase inhibitor. It is an antiviral drug that is used to manage and treat various herpes infections. Each tablet contains 1000 mg of Valacyclovir as its active ingredient.

Drug = Valacyclovir

Strength = 1000 mg

How is it taken?

This medicine may be taken with or without food. May be taken with meals to reduce gastrointestinal discomfort.

Try to take it at the same time each day. It must be taken regularly for it to be effective. 

Take exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor. Do not stop taking it unless instructed by the doctor.

Dosage of Valacyclovir (Valclovir 1000) 1000 mg Tablet

Genital herpes, Herpes simplex infections of the skin and mucous membranes:

Adult: Immunocompetent patients: 500 mg twice a day for 3-5 days for recurrent episodes or up to 10 days for initial episodes. Immunocompromised patients: 1,000 mg twice a day for at least five days for recurrent episodes or up to 10 days for initial episodes. Treatment duration is based on the severity of the clinical condition and immunological status.

 

Herpes zoster (shingles), Herpes zoster ophthalmicus:

Adult: Immunocompetent patients: 1,000 mg three times a day for seven days. Immunocompromised patients: 1,000 mg three times a day for at least seven days and for two days after crusting of lesions.

 

Herpes labialis:

Adult: 2,000 mg 12 hourly for 1 day.

 

Prophylaxis of cytomegalovirus infections in immunocompromised patients:

Adult: Patient following solid organ transplantation: 2,000 mg four times daily, usually for 90 days according to patient response.

 

Suppression of recurrent herpes simplex:

Adult: Immunocompetent patients: 500 mg once daily. Patient with more than ten relapses a year: 250 mg twice a day. Immunocompromised patients: 500 mg twice a day. Re-evaluate treatment after 6-12 months of therapy.

Missed Dose of Valacyclovir (Valclovir 1000) 1000 mg Tablet

If you often forget to take your medicine, let your doctor and pharmacist know.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your usual dosing schedule.

Do not double a dose under any circumstances.

Overdose of Valacyclovir (Valclovir 1000) 1000 mg Tablet

If you think you may have used Valaciclovir more than the usual dose, please seek medical help immediately.

Symptoms of overdose may include the following:

  • Acute renal failure
  • Nausea
  • Vomiting
  • Confusion
  • Agitation
  • Hallucinations
  • Decreased consciousness
  • Coma

Contraindications

People with the following medical conditions should not take Valaciclovir:

  • Hypersensitivity

 

Side Effects

Valaciclovir may have the following side effects:

  • Acute renal failure
  • Agitation
  • Hallucination
  • Confusion
  • Delirium
  • Seizures
  • Encephalopathy
  • Thrombocytopenia
  • Leucopenia
  • Nausea
  • Abdominal pain
  • Vomiting
  • Diarrhea
  • Fatigue
  • Ataxia
  • Fever
  • Urticaria
  • Anaphylaxis (rare)
  • Angioedema
  • Elevated liver enzymes
  • Dehydration
  • Arthralgia
  • Headache
  • Dizziness
  • Decreased consciousness
  • Tremor
  • Dysarthria
  • Renal pain
  • Hematuria
  • Dysmenorrhea
  • Nasopharyngitis
  • Dyspnea
  • Rashes
  • Pruritus
  • Photosensitivity

Potentially Fatal: 

  • Thrombotic thrombocytopenic purpura
  • Hemolytic uremic syndrome

Warnings

Do not take Valacyclovir with the following medicines:

  • Aminoglycosides
  • Organoplatinum compounds
  • Iodinated contrast media
  • Methotrexate
  • Pentamidine
  • Foscarnet
  • Ciclosporin
  • Tacrolimus
  • Probenecid 
  • Cimetidine

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.

This list does not include all medicines that may interact with Valacyclovir.

How Does It Work?

Valaciclovir is rapidly and almost completely converted to aciclovir, then converted to acyclovir monophosphate by a virus-specific enzyme thymidine kinase (TK), then further converted to acyclovir triphosphate by other cellular enzymes. Aciclovir triphosphate competitively inhibits viral DNA synthesis and replication by competing with deoxyguanosine triphosphate for viral DNA polymerase and being incorporated into viral DNA.

Uses 

Valaciclovir is used to treat the following conditions:

  • Herpes zoster (shingles)
  • Herpes zoster ophthalmicus
  • Herpes simplex infections of the skin and mucous membranes
  • Genital herpes
  • Herpes labialis
  • Suppression of recurrent herpes simplex
  • Prophylaxis of cytomegalovirus infections in immunocompromised patients

 

Special Precautions and Connected Warnings

Take special precautions if you have the following conditions:

  • Patients inadequately hydrated or at risk of dehydration
  • Immunocompromised patients
  • Renal and hepatic impairment
  • Elderly
  • Pregnancy
  • Lactation

 

Storage Conditions

  • Store between 15-25°C.
  • Store in a cool, dry place away from the reach of children.
  • Do not use Valaciclovir that is expired or out of date.
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